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February 29, 2012

Reversing Alzheimer's gene 'blockade' restores memory!

A latest research says that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers at the Massachusetts Institute of Technology were able to reverse Alzheimer's symptoms. 

According to the Journal Nature reports, the findings suggests that drugs targeting the enzyme, known as HDAC2, which could be a promising new approach to treating the disease, which affects 5.4 million Americans alone. The number of Alzheimer's victims worldwide is expected to double every 20 years, & President Barack Obama recently set a target date of 2005 to find an effective treatment, according to an MIT statement.

Li-Huei Tsai, director of the Picower Institute for Learning & Memory at MIT, who led the MIT research team, says that HDAC2 inhibitors could achieve that goal, though it would likely take at least 10 years to develop & test such drugs. 

Li-Huei also said, "I would strongly advocate for an active program to develop agents that can contain HDAC2 activity. The disease is so devastating & affects so many people, so I would encourage more people to think about this."

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