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February 27, 2011

Hypoxia kills due to Inflammation!

A well-known fact among Doctors that the lack of oxygen during a major surgery can lead to injuries on Kidneys, Heart muscles or Lungs can be injured as a result. According to a few recent researches, the inflammation is the cause of these injuries. The exception can be seen in athletes, who train their bodies to withstand the shock of lesser oxygen conditions.

A doctor at the University Of Colorado School Of Medicine has got successful in finding a relationship between hypoxia (lack of Oxygen) & the inflammation that severely injures & can even kill the patients who undergo major surgeries. For a precise instance, a kidney transplant could be successfully done through anesthesia, yet it the kidneys may fail to work because of the hypoxia.

"Understanding how hypoxia is linked to inflammation may help save lives of people who 've survived a major surgery only to be faced with potential harm to major organs," says Holger K. Eltzschig, MD (Ph.D). Eltzschig is the same Doctor who found the relationship between hypoxia & inflammation & that was published on Feb 17 in the New England Journal of Medicine. More than one million dollars were funded by the National Institutes of Health top support him for the studies. The answer to that athlete’s exception of surviving in the hypoxic conditions lies at the molecular level.

The body signals a helpful response to deal with low oxygen level through a hypoxia-inducible factor (HIF). This is a protein that sends complex signals to help the body defend itself. Eltzschig says that research should now focus much on how these signals function. "By focusing on the molecular pathways the body uses to battle hypoxia, we may be able help patients who undergo organ transplants, who suffer from infections or who 've cancer. We know the body can do this. Our research goal now is to find out exactly how," says Eltzschig.

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