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December 21, 2011

Way to minimize side-effects of drugs!

People suffering from various diseases like allergies, asthma or even arthritis are more prone to drugs for their treatments, there rise a major question of the side-effects for the intake of those drugs. So there rise more percentage of patients affected from the side-effects too.

Now a latest study reveals that a missing link between the body's bio-clock & sugar metabolism may help avoid the serious side-effects of drugs used in treating allergies, asthma & even arthritis. Scientists discovered that proteins controlling the body's bio-rhythms better known as cryptochromes, also interact with metabolic switches that are targeted by certain anti-inflammatory drugs. 

According to the journal Nature reports, the finding suggests that side-effects of current drugs might be avoided by considering patients' bio rhythms when giving drugs or by developing new drugs that target cryptochromes. The research study lead Ronald M. Evans, professor in Salk's Gene Expression Lab said, "We knew that our sleep & wake cycle are tied to when our bodies process nutrients, but how this happened at the genetic & molecular level was a complete mystery." 

According to a university statement, Evans said, "We've now found the link between these two important systems, which could serve as a model for how other cellular processes are linked & could hold promise for better therapies. Disrupting the normal day-night cycle of activity may prevent a person's biological clock from synchronizing correctly with their daily patterns of nutrient metabolism, & as a result, the body might not store & process sugar normally, leading to metabolic disease." 

Evans concluded by quoting that more broadly, the study may help explain the connection between sleep & nutrient metabolism in our bodies, including why people with jobs that require night work or erratic hours are at higher risk for obesity & diabetes. 

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